Article Navigation
Journal Article
Get access
, Soo Hyun Lee, MD Department of Pathology, Boston Medical Center , Boston, MA , US Search for other works by this author on: Oxford Academic Amaya Pankaj, MD Departments of Pathology, Massachusetts General Hospital , Boston, MA , US Search for other works by this author on: Oxford Academic Steffen Rickelt, PhD Department of Medicine,Massachusetts Institute of Technology , Cambridge, MA , US Search for other works by this author on: Oxford Academic David Ting, MD Department of Medicine,Massachusetts General Hospital Cancer Center , Boston, MA , US Departments of Medicine, Harvard Medical School , Boston , US Search for other works by this author on: Oxford Academic Cristina Ferrone, MD Departments of Surgery, Massachusetts General Hospital , Boston, MA , US Search for other works by this author on: Oxford Academic Deepa T Patil, MD Departments of Medicine, Harvard Medical School , Boston , US Department of Pathology, Brigham and Women’s Hospital , Boston, MA , US Search for other works by this author on: Oxford Academic Omer Yilmaz, MD Departments of Pathology, Massachusetts General Hospital , Boston, MA , US Departments of Medicine, Harvard Medical School , Boston , US Search for other works by this author on: Oxford Academic David Berger, MD Division of General Surgery, Massachusetts General Hospital , Boston, MA , US Search for other works by this author on: Oxford Academic Vikram Deshpande, MD Departments of Medicine, Harvard Medical School , Boston , US Department of Pathology, Beth Israel Deaconess Medical Center , Boston, MA , US Search for other works by this author on: Oxford Academic Osman Yilmaz, MD Department of Pathology, Beth Israel Deaconess Medical Center , Boston, MA , US Departments of Pathology, Harvard Medical School , Boston , US Corresponding author: Osman Yilmaz; osmanhy@gmail.com Search for other works by this author on: Oxford Academic
https://orcid.org/0000-0002-9622-357X American Journal of Clinical Pathology, aqae066, https://doi.org/10.1093/ajcp/aqae066
Published:
13 June 2024
Article history
Received:
26 February 2024
Accepted:
06 May 2024
Published:
13 June 2024
- Views
- Article contents
- Figures & tables
- Video
- Audio
- Supplementary Data
-
Cite
Cite
Soo Hyun Lee, Amaya Pankaj, Steffen Rickelt, David Ting, Cristina Ferrone, Deepa T Patil, Omer Yilmaz, David Berger, Vikram Deshpande, Osman Yilmaz, β2-microglobulin expression is associated with aggressive histology, activated tumor immune milieu, and outcome in colon carcinoma, American Journal of Clinical Pathology, 2024;, aqae066, https://doi.org/10.1093/ajcp/aqae066
Close
Search
Close
Search
Advanced Search
Search Menu
Abstract
Objectives
We sought to assess the expression of human leukocyte antigen (HLA) proteins and β2-microglobulin (B2M) in tumor cells and the relationship with immune microenvironment and outcome in colorectal cancer (CRC).
Methods
A total of 953 CRC cases were evaluated by immunohistochemistry for HLA class I, HLA class II, and B2M. The expression level of these biomarkers was correlated with clinicopathologic information, BRAF V600E and mismatch repair (MMR) proteins, and the quantitated expression levels of immune cells (CD8 and CD163) and immune regulatory proteins (FoxP3, programmed cell death 1 ligand 1 [PD-L1], and LAG3).
Results
We found that B2M-low tumors were statistically correlated with aggressive histologic features, including higher stage, higher grade, extramural venous invasion, perineural invasion, and distant metastasis. Expression of B2M was positively correlated (R2=0.3) and significantly associated with MMR-deficient tumors (P<.001); B2M-low tumors were also associated with an “immune cold”’ microenvironment, including a reduced number of immune cells (CD8 and CD163), reduced expression of immune regulatory proteins by immune cells (PD-L1, FoxP3, and LAG3), and reduced tumor cell expression of PD-L1. These B2M-low tumors correlated with lower disease-specific survival (P=.018), a finding that maintained significance only for the proficient MMR cohort (P=.037).
Conclusions
Our findings suggest that B2M expression may support predictive models for both outcome and checkpoint inhibitor therapy treatment response for colorectal adenocarcinoma.
© The Author(s) 2024. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)
You do not currently have access to this article.
Download all slides
Sign in
Get help with access
-
American Society for Clinical Pathology members
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Sign in Register
Institutional access
- Sign in with a library card
- Sign in with username/password
- Recommend to your librarian
Sign in through your institution
Sign in through your institution
Institutional account management
Sign in as administrator
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
- Click Sign in through your institution.
- Select your institution from the list provided, which will take you to your institution's website to sign in.
- When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
- Click Sign in through society site.
- When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
- View your signed in personal account and access account management features.
- View the institutional accounts that are providing access.
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.
Purchase
Subscription prices and ordering for this journal
Purchasing options for books and journals across Oxford Academic
Short-term Access
To purchase short-term access, please sign in to your personal account above.
Don't already have a personal account? Register
β2-microglobulin expression is associated with aggressive histology, activated tumor immune milieu, and outcome in colon carcinoma - 24 Hours access
EUR €38.00
GBP £33.00
USD $41.00
Rental
This article is also available for rental through DeepDyve.
Advertisem*nt
Citations
Views
26
Altmetric
More metrics information
Metrics
Total Views 26
16 Pageviews
10 PDF Downloads
Since 6/1/2024
| Month: | Total Views: |
|---|---|
| June 2024 | 26 |
Citations
Powered by Dimensions
Altmetrics
Email alerts
Article activity alert
New issue alert
Receive exclusive offers and updates from Oxford Academic
Citing articles via
Google Scholar
-
Latest
-
Most Read
-
Most Cited
Advertisem*nt
